Patients with cirrhosis who present with upper GI bleeding (from varices or other causes) should be given prophylactic antibiotics, preferably before endoscopy although effectiveness has also been demonstrated when given after endoscopy.
Recommended Prophylactic Regimen (Continue for 7 days)
Ceftriaxone 1g IV q24h
If severe pen-allergy or cephalosporin allergy (e.g. anaphylaxis, angioedemia) consult Medical Microbiologist or Infectious Disease physician.